Three-Component, One-Pot Sequential Synthesis of N-Aryl, N'-Alkyl Barbiturates

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• 作者：Alessandro Volonterio ; Matteo Zanda
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：March 1, 2007
• 年：2007
• 卷：9
• 期：5
• 页码：841 - 844
• 全文大小：76K
• 年卷期：v.9,no.5(March 1, 2007)
• ISSN：1523-7052

文摘

BLE>Condensation between N-alkyl, N'-aryl carbodiimides and malonic acid monoesters leads to a high-yield formation of N-acyl urea derivativesthat could be cyclized to C-monosubstituted barbiturates by addition of a suitable base in a one-pot sequential fashion. In the presence of anelectrophile, the last step gives rise to a one-pot, three-component sequential synthesis of fully substituted barbiturates.