Fate of PLA and PCL-Based Polymeric Nanocarriers in Cellular and Animal Models of Triple-Negative Breast Cancer

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• 作者：Leopoldo Sitia ; Raffaele Ferrari ; Martina B. Violatto ; Laura Talamini ; Luca Dragoni ; Claudio Colombo ; Laura Colombo ; Monica Lupi ; Paolo Ubezio ; Maurizio D’Incalci ; Massimo Morbidelli ; Mario Salmona ; Davide Moscatelli ; Paolo Bigini
• 刊名：Biomacromolecules
• 出版年：2016
• 出版时间：March 14, 2016
• 年：2016
• 卷：17
• 期：3
• 页码：744-755
• 全文大小：675K
• ISSN：1526-4602

文摘

An integrated platform to assess the interaction between nanocarriers and biological matrices has been developed by our group using poly methyl-methacrylate nanoparticles. In this study, we exploited this platform to evaluate the behavior of two biodegradable formulations, poly-ε-caprolactone (PCL₃) and poly lactic-acid (PLA₈), respectively, in cellular and animal models of triple-negative breast cancer (TNBC). Both NPs shared the main physicochemical parameters (size, shape, ζ-potential) and exclusively differentiated on the material on which they are composed. Our results showed that (1) PLA₈ NPs, systemically injected in mice, underwent rapid degradation without penetration into tumors; (2) PLA₈ NPs were not internalized in the human TNBC cell line (MDA-MB-231); (3) PCL₃ NPs had a longer bioavailability, reached the tumor parenchyma, and efficiently penetrated in MDA-MB-231 cells. Our data highlight the relevance of the material selection to both improve bioavailability and target tropism, and make PCL₃ NPs an interesting tool for the development of nanodrugs against TNBC.