Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida

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• 作者：Zengwei Luo ; Fuqian Wang ; Jinwen Zhang ; Xingyao Li ; Mengke Zhang ; Xincai Hao ; Yongbo Xue ; Yan Li ; F. David Horgen ; Guangmin Yao ; Yonghui Zhang
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：December 28, 2012
• 年：2012
• 卷：75
• 期：12
• 页码：2113-2120
• 全文大小：328K
• 年卷期：v.75,no.12(December 28, 2012)
• ISSN：1520-6025

文摘

Seven new alkaloids, N-methylhemeanthidine chloride (1), N-methyl-5,6-dihydroplicane (5), O-methylnerinine (6), N-ethoxycarbonylethylcrinasiadine (7), N-ethoxycarbonylpropylcrinasiadine (8), N-phenethylcrinasiadine (9), and N-isopentylcrinasiadine (10), together with eight known alkaloids, hemeanthamin (2), 3-epimacronine (3), (+)-tazettine (4), N-methylcrinasiadine (11), trisphaeridine (12), 5,6-dihydrobicolorine (13), lycorine (14), and nigragillin (15), were isolated from the whole plants of Zephyranthes candida. The structures of the new compounds were established by spectroscopic data interpretation, with single-crystal X-ray diffraction analysis performed on 1. The absolute configuration of 3-epimacronine (3) was determined by single-crystal X-ray diffraction analysis with Cu K伪 irradiation. Compounds 1鈥?b>15 were evaluated for their in vitro cytotoxicity against five human cancer cell lines and the Beas-2B immortalized (noncancerous) human bronchial epithelial cell line. Compounds 1, 2, 9, and 14 exhibited cytotoxicity with IC₅₀ values ranging from 0.81 to 13 渭M with selectivity indices as high as 10 when compared to the Beas-2B cell line.