Experimental and Theoretical Investigation of the Phase Behavior of Naproxen in Supercritical CO2
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- 作者：Michael Trk ; Thomas Kraska
- 刊名：Journal of Chemical & Engineering Data
- 出版年：2009
- 出版时间：May 14, 2009
- 年：2009
- 卷：54
- 期：5
- 页码：1592-1597
- 全文大小：149K
- 年卷期：v.54,no.5(May 14, 2009)
- ISSN：1520-5134
文摘
New experimental solubility data of Naproxen in supercritical CO2 for (313 to 353) K and pressures ranging from (15 to 40) MPa are presented. This covers the range where processes with supercritical fluids such as Rapid Expansion from Supercritical Fluids are typically performed. In addition, the solid−liquid−gas equilibrium line for the CO2 + Naproxen system was determined from (0.1 to 30) MPa. The solubility data are correlated by three different methods: two methods for the density−solubility correlation and one method for the pressure−solubility correlation. Different literature data and predictions of the sublimation pressure of Naproxen, which are required for the solubility correlation, are compared.