Multicomponent Solvent-Free Synthesis Of Benzimidazolyl Imidazo[1,2-a]-pyridine Under Microwave Irradiation
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- 作者：Barnali Maiti ; Kaushik Chanda ; Manikandan Selvaraju ; Chih-Chung Tseng ; Chung-Ming Sun
- 刊名：ACS Combinatorial Science
- 出版年：2013
- 出版时间：June 10, 2013
- 年：2013
- 卷：15
- 期：6
- 页码：291-297
- 全文大小：402K
- 年卷期：v.15,no.6(June 10, 2013)
- ISSN：2156-8944
文摘
A novel one-pot, three-component reaction employing variously substituted benzimidazole-linked amino pyridines, aldehydes, and isonitriles catalyzed by scandium(III) triflate under solvent-free conditions were accomplished. This new synthetic methodology facilitates the rapid generation of intricate molecular frameworks in three-dimensional fashion leading to benzimidazole-imidazo[1,2-a] pyridines. This approach is envisioned as an environmentally benign process and a simple operation to the biological interesting compounds. The present synthetic sequence permits the introduction of three points of structural diversity to expand chemical space with high purity and excellent yields.