Selective Metal-Ion-Mediated Vesicle Adhesion Based on Dynamic Self-Organization of a Pyrene-Appended Glutamic Acid

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• 作者：Pengyao Xing ; Yajie Wang ; Minmin Yang ; Yimeng Zhang ; Bo Wang ; Aiyou Hao
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：July 13, 2016
• 年：2016
• 卷：8
• 期：27
• 页码：17676-17684
• 全文大小：562K
• 年卷期：0
• ISSN：1944-8252

文摘

Vesicles with dynamic membranes provide an ideal model system for investigating biological membrane activities, whereby vesicle aggregation behaviors including adhesion, fusion, fission, and membrane contraction/extension have attracted much attention. In this work we utilize an aromatic amino acid (pyrene-appended glutamic acid, PGlu) to prepare nanovesicles that aggregate to form vesicle clusters selectively induced by Fe³⁺ or Cu²⁺, and the vesicles transform into irregular nano-objects when interacting with Al³⁺. Vesicle clusters have better stability than pristine vesicles, which hinders the spontaneous morphological transformation from vesicles into lamellar nanosheets with long incubation period. The difference between complexation of Fe³⁺ and Al³⁺ with vesicles was studied by various techniques. On the basis of metal ion–vesicle interactions, this self-assembled nanovesicle system also behaves as an effective fluorescent sensor for Fe³⁺ and Al³⁺, which cause fluorescence quenching and enhanced excimer emission, respectively.