Pt-Catalyzed Enantioselective Diboration of Terminal Alkenes with B2(pin)2

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• 作者：Laura T. Kliman ; Scott N. Mlynarski ; James P. Morken
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：September 23, 2009
• 年：2009
• 卷：131
• 期：37
• 页码：13210-13211
• 全文大小：152K
• 年卷期：v.131,no.37(September 23, 2009)
• ISSN：1520-5126

文摘

The Pt-catalyzed enantioselective addition of bis(pinacolato)diboron to simple monosubstituted alkenes is described. This reaction occurs in the presence of a readily available chiral phosphonite ligand and is effective with a variety of terminal alkene substrates. Importantly, the reaction can operate with catalyst loadings of only 1 mol % Pt. While oxidation of the intermediate 1,2-bis(boronate) ester provides the chiral 1,2-diol as the reaction product, the intermediate may also be subjected to homologation/oxidation to furnish a chiral 1,4-diol as the reaction product.