Enhanced Nanoparticle Size Control by Extending LaMer鈥檚 Mechanism

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• 作者：Erika C. Vreeland ; John Watt ; Gretchen B. Schober ; Bradley G. Hance ; Mariah J. Austin ; Andrew D. Price ; Benjamin D. Fellows ; Todd C. Monson ; Nicholas S. Hudak ; Lorena Maldonado-Camargo ; Ana C. Bohorquez ; Carlos Rinaldi ; Dale L. Huber
• 刊名：Chemistry of Materials
• 出版年：2015
• 出版时间：September 8, 2015
• 年：2015
• 卷：27
• 期：17
• 页码：6059-6066
• 全文大小：489K
• ISSN：1520-5002

文摘

The synthesis of well-defined nanoparticle materials has been an area of intense investigation, but size control in nanoparticle syntheses is largely empirical. Here, we introduce a general method for fine size control in the synthesis of nanoparticles by establishing steady state growth conditions through the continuous, controlled addition of precursor, leading to a uniform rate of particle growth. This approach, which we term the 鈥渆xtended LaMer mechanism鈥?allows for reproducibility in particle size from batch to batch as well as the ability to predict nanoparticle size by monitoring the early stages of growth. We have demonstrated this method by applying it to a challenging synthetic system: magnetite nanoparticles. To facilitate this reaction, we have developed a reproducible method for synthesizing an iron oleate precursor that can be used without purification. We then show how such fine size control affects the performance of magnetite nanoparticles in magnetic hyperthermia.