Prospective on Mycobacterium tuberculosis Proteomics
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- 作者：M. Carolina Mehaffy ; Nicole A. Kruh-Garcia ; Karen M. Dobos
- 刊名：Journal of Proteome Research
- 出版年：2012
- 出版时间：January 1, 2012
- 年：2012
- 卷：11
- 期：1
- 页码：17-25
- 全文大小：905K
- 年卷期：v.11,no.1(January 1, 2012)
- ISSN：1535-3907
文摘
Mycobacterium tuberculosis, the causative agent of tuberculosis, remains one of the most prevalent human pathogens in the world. Knowledge regarding the bacilli鈥檚 physiology as well as its mechanisms of virulence, immunogenicity, and pathogenesis has increased greatly in the last three decades. However, the function of about one-quarter of the Mtb coding genome and the precise activity and protein networks of most of the Mtb proteins are still unknown. Protein mass spectrometry and a new interest in research toward the field of functional proteomics have given a new light to the study of this bacillus and will be the focus of this review. We will also discuss new perspectives in the proteomics field, in particular targeted mass spectrometry methods and their potential applications in TB research and discovery.