Effect of Side Group Chemistry on the Properties of Biodegradable L-Alanine Cosubstituted Polyphosphazenes
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- 作者：Anurima Singh ; Nicholas R. Krogman ; Swaminathan Sethuraman ; Lakshmi S. Nair ; Jacqueline L. Sturgeon ; Paul W. Brown ; Cato T. Laurencin ; and Harry R. Allcock
- 刊名：Biomacromolecules
- 出版年：2006
- 出版时间：March 2006
- 年：2006
- 卷：7
- 期：3
- 页码：914 - 918
- 全文大小：186K
- 年卷期：v.7,no.3(March 2006)
- ISSN：1526-4602
文摘
Biodegradable polyphosphazenes have been investigated for a variety of applications, such as controlled drugdelivery matrixes, tissue-engineering scaffolds, membranes, and bone-type composites. In this study we haveevaluated the effect of side group chemistry on the properties of biodegradable phosphazene polymers that containethyl alanato side groups together with ethyl glycinato, p-methylphenoxy, or p-phenylphenoxy side groups. Thepolymers were synthesized by a macromolecular substitution route. The molecular weights of aryloxy/aminoacid ester cosubstituted polymers were much higher than the amino acid ester substituted polyphosphazenesdescribed earlier. Polymer properties, such as glass transition temperature, hydrolytic degradation, surface wettability,tensile strength, and modulus of elasticity varied over a wide range following changes to the type of co-substituentson the polymer backbone. The glass transition temperatures varied from -10 to 35 
C and increased with thebulkiness of the side groups. Polymer films in phosphate buffer saline solution showed molecular weight declinesranging from 58% to >80% and mass loss ranging from 4% to 90% over a period of 7 weeks. Water contactangles for polymer films varied from 63 to 107, with the highest angles for the alanine ethyl ester andp-phenylphenoxy cosubstituted polyphosphazene. The tensile strengths were in the range of 2.4-7.6 MPa andthe modulus of elasticity was in the range of 31.4-455.9 MPa. Thus, in this study we have demonstrated thetunability of biodegradable polyphosphazenes to suit a range of biomedical applications.
C and increased with thebulkiness of the side groups. Polymer films in phosphate buffer saline solution showed molecular weight declinesranging from 58% to >80% and mass loss ranging from 4% to 90% over a period of 7 weeks. Water contactangles for polymer films varied from 63 to 107, with the highest angles for the alanine ethyl ester andp-phenylphenoxy cosubstituted polyphosphazene. The tensile strengths were in the range of 2.4-7.6 MPa andthe modulus of elasticity was in the range of 31.4-455.9 MPa. Thus, in this study we have demonstrated thetunability of biodegradable polyphosphazenes to suit a range of biomedical applications.