Microwave-Assisted Polyol Synthesis of Gadolinium-Doped Green Luminescent Carbon Dots as a Bimodal Nanoprobe

详细信息    查看全文

• 作者：Ningqiang Gong ; Hao Wang ; Shuai Li ; Yunlong Deng ; Xiao鈥檃i Chen ; Ling Ye ; Wei Gu
• 刊名：Langmuir
• 出版年：2014
• 出版时间：September 16, 2014
• 年：2014
• 卷：30
• 期：36
• 页码：10933-10939
• 全文大小：391K
• ISSN：1520-5827

文摘

The development of multimodal nanoprobes is highly desired in medical imaging because it integrates the advantages of multiple imaging modes. In this study, the gadolinium-doped green luminescent carbon dots (Gd-CDs) were prepared by the simple one-step microwave-assisted polyol method. The obtained Gd-CDs emitted a unique green photoluminescence with a quantum yield of 5.4%. The Gd-CDs exhibited a low cytotoxicity and could optically label the C6 glioma cells. Meanwhile, the r₁ relaxivity of Gd-CDs was measured to be 11.356 mM^鈥? s^鈥?. This high r₁ value together with the r₂/r₁ ratio close to 1 nominates Gd-CDs as an excellent T₁ contrast agent for magnetic resonance imaging. These Gd-CDs combining two complementary imaging modalities are therefore a promising bimodal nanoprobe in medical imaging for a better diagnosis.