Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation
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- 作者：Zhiguo J. Song ; David M. Tellers ; Peter G. Dormer ; Daniel Zewge ; Jacob M. Janey ; Andrew Nolting ; Dietrich Steinhuebel ; Steven Oliver ; Paul N. Devine ; David M. Tschaen
- 刊名：Organic Process Research & Development
- 出版年：2014
- 出版时间：March 21, 2014
- 年：2014
- 卷：18
- 期：3
- 页码：423-430
- 全文大小：352K
- 年卷期：v.18,no.3(March 21, 2014)
- ISSN：1520-586X
文摘
A practical synthesis of a macrocyclic HCV protease inhibitor, MK-1220, is described. The key features are a new synthesis of the trisubstituted isoquinoline, Sonogashira fragment coupling, and a high-yielding, 18-membered macrolactam formation.