Determination and Characterization of Hydroxylated Polychlorinated Biphenyls (OH-PCBs) in Serum and Adipose Tissue of Japanese Women Diagnosed with Breast Cancer

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• 作者：Kei Nomiyama ; Tomonori Yonehara ; Saori Yonemura ; Megumi Yamamoto ; Chihaya Koriyama ; Suminori Akiba ; Ryota Shinohara ; Minoru Koga
• 刊名：Environmental Science & Technology
• 出版年：2010
• 出版时间：April 15, 2010
• 年：2010
• 卷：44
• 期：8
• 页码：2890-2896
• 全文大小：306K
• 年卷期：v.44,no.8(April 15, 2010)
• ISSN：1520-5851

文摘

In the present study, we analyze and characterize the levels of PCBs and OH-PCBs in serum and breast adipose tissue, and measure TH (total 3,5,5′-triiodothyronine (tT3) and total l-thyroxine (tT4)) levels in serum of Japanese women diagnosed with breast cancer (n = 51) to know how PCBs affect thyroid hormone homeostasis. Concentrations of Σ₉₀OH-PCBs in serum and adipose tissues were 630 pg g⁻¹ serum wet wt. and 140 pg/ g⁻¹ lipid wt., respectively, and the levels of OH−PCBs in adipose tissues were 4−5 times lower than in serum. The tT3 and tT4 concentrations in serum (n = 20) were 1.3 ng g⁻¹ serum wet wt. and 62 ng g⁻¹ serum wet wt., respectively. Among all the OH-PCBs, 4′-OH-CB101/120, 4-OH-CB107/4′-OH-CB108, 3′-OH-CB138, 4-OH-CB146, 3-OH-CB153, 4′-OH-CB172, and 4-OH-CB187 were the dominant isomers in serum. No significant correlation between the concentrations of the TH and OH-PCBs in serum was observed (p > 0.05). The results indicated that the relationship between the OH-PCB levels and the thyroid hormone markers was rare. From analysis of two kinds of human biological samples, it was estimated that OH-PCBs have little effect on thyroid hormone homeostasis.