Chemistry of the Versatile (Hydroxymethyl)phosphinyl P(O)CH2OH Functional Group

详细信息    查看全文

• 作者：Olivier Berger ; Laurent Gavara ; Jean-Luc Montchamp
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：July 6, 2012
• 年：2012
• 卷：14
• 期：13
• 页码：3404-3407
• 全文大小：236K
• 年卷期：v.14,no.13(July 6, 2012)
• ISSN：1523-7052

文摘

(Hydroxymethyl)phosphorus compounds are well-known and valuable compounds in general; however the use of (hydroxymethyl)phosphinates R¹P(O)(OR²)CH₂OH in particular has been much more limited. The potential of this functionality has not yet been fully realized because the mild unmasking of the hydroxymethyl group was not available. The mild oxidative conversion of R¹P(O)(OR²)CH₂OH into R¹P(O)(OR²)H using the Corey鈥揔im oxidation is described. Other reactions preserving the methylene carbon are also reported.