Microwave-Assisted Copper(II)-Catalyzed One-Pot Four-Component Synthesis of Multifunctionalized Dihydropyridines
详细信息 查看全文
- 作者：Kalyan Kumar Pasunooti ; Chantel Nixon Jensen ; Hua Chai ; Min Li Leow ; Da-Wei Zhang ; Xue-Wei Liu
- 刊名：Journal of Combinatorial Chemistry
- 出版年：2010
- 出版时间：July 12, 2010
- 年：2010
- 卷：12
- 期：4
- 页码：577-581
- 全文大小：144K
- 年卷期：v.12,no.4(July 12, 2010)
- ISSN：1520-4774
文摘
A fast and highly efficient copper-catalyzed multicomponent synthesis of 1,4-dihydropyridines under microwave irradiation is described. The protocol utilizes mild reaction conditions with low catalytic loading, leading to high yields. This methodology provides us with biologically active 1,4-dihydropyridine library for medicinal chemistry applications.