A General and Practical Alternative to Polar Aprotic Solvents Exemplified on an Amide Bond Formation

详细信息    查看全文

• 作者：Fabrice Gallou ; Pengfei Guo ; Michael Parmentier ; Jianguang Zhou
• 刊名：Organic Process Research & Development
• 出版年：2016
• 出版时间：July 15, 2016
• 年：2016
• 卷：20
• 期：7
• 页码：1388-1391
• 全文大小：191K
• 年卷期：0
• ISSN：1520-586X

文摘

A counter-intuitive observation has been made that addition of an organic solvent to a reaction mixture being used under micellar conditions is the key to success. This empirical approach has since proven to be particularly general in a variety of transformations, ranging from C–C cross-couplings (Heck, Sonogashira, Suzuki), oxidations, and reductions, thus providing a sustainable alternative to some of the undesirable solvents classically used.