Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei
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- 作者：Heng Zheng ; Qiong Chen ; Mengke Zhang ; Yongji Lai ; Liang Lei ; Penghua Shu ; Jinwen Zhang ; Yongbo Xue ; Zengwei Luo ; Yan Li ; Guangmin Yao ; Yonghui Zhang
- 刊名：Journal of Natural Products
- 出版年：2013
- 出版时间：December 27, 2013
- 年：2013
- 卷：76
- 期：12
- 页码：2253-2262
- 全文大小：470K
- ISSN：1520-6025
文摘
Fifteen new ent-kaurane diterpenoids, compounds 1鈥?b>15, and two known analogues, 4-epi-henryine A (16) and leukamenin E (17), were isolated from the whole plants of Salvia cavaleriei. The structures of the new compounds were established by spectroscopic methods, and their absolute configurations were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu K伪 radiation. Compounds 1鈥?b>15 were evaluated for their cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480, as well as the noncancerous Beas-2B cell line. Compounds 1鈥?b>10, 12, 14, and 15 showed broad-spectrum cytotoxicity, with compounds 1, 3, 6鈥?b>10, 12, and 15 exhibiting more potent cytotoxicity than the positive control, cis-platin, with IC50 values ranging from 0.65 to 6.4 渭M.