Wilsonols A鈥?/b>L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii
详细信息 查看全文
- 作者：Penghua Shu ; Xialan Wei ; Yongbo Xue ; Weijie Li ; Jinwen Zhang ; Ming Xiang ; Mengke Zhang ; Zengwei Luo ; Yan Li ; Guangmin Yao ; Yonghui Zhang
- 刊名：Journal of Natural Products
- 出版年：2013
- 出版时间：July 26, 2013
- 年：2013
- 卷：76
- 期：7
- 页码：1303-1312
- 全文大小：469K
- 年卷期：v.76,no.7(July 26, 2013)
- ISSN：1520-6025
文摘
Twelve new megastigmane sesquiterpenoids, wilsonols A鈥揕 (1鈥?b>12), were isolated from the leaves of Cinnamomum wilsonii, along with seven known analogues (13鈥?b>19). The structures of compounds 1鈥?b>12 were established by spectroscopic analyses. The absolute configurations of 1鈥?b>5 were determined by single-crystal X-ray diffraction analysis with Cu K伪 irradiation, and the absolute configurations of 6鈥?b>12 were determined by the modified Mosher鈥檚 method. Compounds 1鈥?b>9 and 13鈥?b>19 were evaluated for in vitro cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW-480, and compared against the Beas-2B immortalized (noncancerous) human bronchial epithelial cell line. Compound 13 exhibited IC50 values ranging from 2.5 to 12 渭M and selectivity indices of >10 against SMMC-7721, A-549, and MCF-7 cell lines. Selected compounds were evaluated for in vitro immunomodulatory activity.