Combining Ruthenium(II) Complexes with Metal–Organic Frameworks to Realize Effective Two-Photon Absorption for Singlet Oxygen Generation
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- 作者：Wenxiang Zhang ; Bin Li ; Heping Ma ; Liming Zhang ; Yunlong Guan ; Yihe Zhang ; Xindan Zhang ; Pengtao Jing ; Shumei Yue
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2016
- 出版时间：August 24, 2016
- 年：2016
- 卷：8
- 期：33
- 页码：21465-21471
- 全文大小：526K
- 年卷期：0
- ISSN：1944-8252
文摘
Singlet oxygen (<sup>1sup>O<sub>2sub>), as a reactive oxygen species, has garnered serious attention in physical, chemical, and biological studies. In this paper, we designed and synthesized a new type of singlet-oxygen generation system by exchanging cationic ruthenium complexes (RCs) into anionic bio-MOF-1. The resulting bio-MOF-1&RCs can be used as effective photocatalysts for generation of singlet oxygen under both single-photon and two-photon excitation. Especially, the excellent two-photon absorption (TPA) behavior of bio-MOF-1&RCs aroused our interest greatly because their two-photon absorption band lies in the optical window of biological tissue. Here, we measured the ability of bio-MOF-1&RCs to generate <sup>1sup>O<sub>2sub> by irradiation under both 490 and 800 nm wavelength light in DMF. 1,3-Diphenylisobenzofuran (DPBF) and 2′,7′-dichlorofluorescein (DCFH) were used as typical <sup>1sup>O<sub>2sub> traps to detect and evaluate the efficiency of generation of <sup>1sup>O<sub>2sub> under single-photon and two-photon excitation, respectively. Results indicated that bio-MOF-1&[Ru(phen)<sub>3sub>]<sup>2+sup> was able to effectively generate <sup>1sup>O<sub>2sub> under both conditions. Our work creates a novel synergistic TPA system with the excellent photophysical properties of RCs and the unique microporous structure benefit of MOFs, which may open a new avenue for creation of a cancer treatment system with both photodynamic therapy and chemotherapy.