Octaminomycins A and B, Cyclic Octadepsipeptides Active against Plasmodium falciparum
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- 作者：Jun-Pil Jang ; Toshihiko Nogawa ; Yushi Futamura ; Takeshi Shimizu ; Daisuke Hashizume ; Shunji Takahashi ; Jae-Hyuk JangJong Seog Ahn ; Hiroyuki Osada
- 刊名：Journal of Natural Products
- 出版年：2017
- 出版时间：January 27, 2017
- 年：2017
- 卷：80
- 期：1
- 页码：134-140
- 全文大小：399K
- ISSN：1520-6025
文摘
Two new cyclic octadepsipeptides, octaminomycins A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces sp. RK85-270 based on Natural Products Plot screening. Their structures were elucidated on the basis of HRESIMS, 1D and 2D NMR spectroscopic data, and MS/MS experiments for sequence analysis. The absolute configurations of the constituent amino acid residues were determined by a combination of single-crystal X-ray diffraction and Marfey’s methodology. Notably, octaminomycins A (1) and B (2) showed good in vitro antiplasmodial activity against chloroquine-sensitive as well as chloroquine-resistant strains with no cytotoxicity up to 30 μM.