Advances in the Enzymatic Reduction of Ketones

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• 作者：Jeffrey C. Moore ; David J. Pollard ; Birgit Kosjek ; Paul N. Devine
• 刊名：Accounts of Chemical Research
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：40
• 期：12
• 页码：1412 - 1419
• 全文大小：189K
• 年卷期：v.40,no.12(December 2007)
• ISSN：1520-4898

文摘

Historically, biocatalytic ketone reductions involved the use of Baker's yeast. Within the last five years, a significant and growing number of isolated ketoreductases have become available that have rendered yeast-based reductions obsolete. The broad substrate range and exquisite selectivities of these enzymes repeatedly outperform other ketone reduction chemistries, making biocatalysis the general method of choice for ketone reductions. Presented here is a summary of our understanding of the capabilities and limitations of these enzymes.