Stochastic Theory of Multiple-Site Linear Adsorption Chromatography

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• 作者：Alberto Cavazzini ; Maurizio Remelli ; Francesco Dondi ; and Attila Felinger
• 刊名：Analytical Chemistry
• 出版年：1999
• 出版时间：August 15, 1999
• 年：1999
• 卷：71
• 期：16
• 页码：3453 - 3462
• 全文大小：115K
• 年卷期：v.71,no.16(August 15, 1999)
• ISSN：1520-6882

文摘

The problem of multiple-site adsorption chromatographyis connected with a great number of questions of bothchromatographic nature (e.g., the effects of surface heterogeneity on the column efficiency and on the peak shapeparameters) and physical chemical relevance (e.g., thestudy of residence time in one sorption step on heterogeneous surfaces). In this study, the multiple-site adsorption, under linear conditions, is considered by using themolecular dynamic theory of chromatography. The probabilistic description is made by means of the characteristicfunction method and the solution is obtained under themost general conditions of surface heterogeneity. Differentcases of surface energy distribution are considered.Relevant chromatographic attributes and the peak shapeparameters-skew and excess-are investigated for heterogeneous stationary-phase surfaces. The chromatograms show that slow kinetics and surface heterogeneityhave momentous impact on peak tailing. The equivalenceof the stochastic model and the lumped kinetic model isdemonstrated.