Rheology and Adhesion of Poly(acrylic acid)/Laponite Nanocomposite Hydrogels as Biocompatible Adhesives

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• 作者：Muxian Shen ; Li Li ; Yimin Sun ; Jun Xu ; Xuhong Guo ; Robert K. Prud’homme
• 刊名：Langmuir
• 出版年：2014
• 出版时间：February 18, 2014
• 年：2014
• 卷：30
• 期：6
• 页码：1636-1642
• 全文大小：459K
• ISSN：1520-5827

文摘

Biocompatible nanocomposite hydrogels (NC gels) consisting of poly(acrylic acid) (PAA) and nanosized clay (Laponite) were successfully synthesized by in situ free-radical polymerization of acrylic acid (AA) in aqueous solutions of Laponite. The obtained NC gels were uniform and transparent. Their viscosity, storage modulus G鈥? and loss modulus G鈥?increased significantly upon increasing the content of Laponite and the dose of AA, while exhibiting a maximum with increasing the neutralization degree of AA. They showed tunable adhesion by changing the dose of Laponite and monomer as well as the neutralization degree of AA, as determined by 180掳 peel strength measurement. The maximal adhesion was shown when reaching a balance between cohesion and fluidity. A homemade Johnson鈥揔endall鈥揜oberts (JKR) instrument was employed to study the surface adhesion behavior of the NC gels. The combination of peel strength, rheology, and JKR measurements offers the opportunity of insight into the mechanism of adhesion of hydrogels. The NC gels with tunable adhesion should be ideal candidates for dental adhesive, wound dressing, and tissue engineering.