Practical Asymmetric Synthesis of Amathaspiramides B, D, and F

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• 作者：Sen-Lin Cai ; Ran Song ; Han-Qing Dong ; Guo-Qiang Lin ; Xing-Wen Sun
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：18
• 期：9
• 页码：1996-1999
• 全文大小：340K
• 年卷期：0
• ISSN：1523-7052

文摘

The practical asymmetric synthesis of amathaspiramides B, D, and F has been accomplished by utilizing an aza-Barbier allylation as the key step to construct the common intermediate with two adjacent stereocenters. A kinetically controlled cyclization to build the challenging thermodynamically less stable 8R-hemiaminal moiety is also important in the synthesis of amathaspiramide D. The route is readily scalable, and gram quantity of the final product D has been prepared.