Metal Cocatalyzed Tandem Alkynylative Cyclization Reaction of in Situ Formed N-Iminoisoquinolinium Ylides with Bromoalkynes via C鈥揌 Bond Activation
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- 作者：Ping Huang ; Qin Yang ; Zhiyuan Chen ; Qiuping Ding ; Jingshi Xu ; Yiyuan Peng
- 刊名：The Journal of Organic Chemistry
- 出版年：2012
- 出版时间：September 21, 2012
- 年：2012
- 卷：77
- 期：18
- 页码：8092-8098
- 全文大小：371K
- 年卷期：v.77,no.18(September 21, 2012)
- ISSN：1520-6904
文摘
Silver triflate and copper(I) iodide cocatalyzed direct alkynylation and cyclization reaction of in situ formed N-iminoisoquinolinium ylides with bromoalkynes is described. The reaction proceeds efficiently through a combination of C鈥揌 activation and subsequent tandem reaction in one pot, leading to diverse H-pyrazolo[5,1-a]isoquinolines in good yields under mild reaction conditions.