Modulators of the Nuclear Receptor Retinoic Acid Receptor-Related Orphan Receptor-纬 (ROR纬 or RORc)

详细信息    查看全文

• 作者：Benjamin P. Fauber ; Steven Magnuson
• 刊名：Journal of Medicinal Chemistry
• 出版年：2014
• 出版时间：July 24, 2014
• 年：2014
• 卷：57
• 期：14
• 页码：5871-5892
• 全文大小：1003K
• ISSN：1520-4804

文摘

As the biology surrounding the nuclear receptor retinoic acid receptor-related orphan receptor-gamma (ROR纬 or RORc) continues to evolve, significant effort has been invested in discovering modulators of this potentially important target for the treatment of metabolic and immunological diseases. Several major pharmaceutical and biotechnology companies have disclosed RORc inhibitors or partnered with other players in the field. In this perspective, we discuss both the biology and the underlying structural biology of RORc, and summarize the RORc modulators disclosed in the scientific and patent literature.