Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)
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- 作者：Robert H. Bradbury ; Rowena Callis ; Gregory R. Carr ; Huawei Chen ; Edwin Clark ; Lyman Feron ; Steve Glossop ; Mark A. Graham ; Maureen Hattersley ; Chris Jones ; Scott G. Lamont ; Gilles Ouvry ; Anil Patel ; Joe Patel ; Alfred A. Rabow ; Craig A. Roberts ; Stephen Stokes ; Natalie Stratton ; Graeme E. Walker ; Lara Ward ; David Whalley ; David Whittaker ; Gail Wrigley ; Michael J. Waring
- 刊名：Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：September 8, 2016
- 年：2016
- 卷：59
- 期：17
- 页码：7801-7817
- 全文大小：610K
- 参考文献：
- ISSN：1520-4804
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