In Situ Observation of Polymorphic Transition during Crystallization of Organic Compounds Showing Preferential Enrichment By Means Of Temperature-Controlled Video-Microscopy and Time-Resolved X-ray Powder Diffraction
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- 作者：Hiroki TakahashiSekai Iwama ; Simon Clevers ; Stéphane Veesler ; Gérard Coquerel ; Hirohito Tsue ; Rui Tamura
- 刊名：Crystal Growth & Design
- 出版年：2017
- 出版时间：February 1, 2017
- 年：2017
- 卷：17
- 期：2
- 页码：671-676
- 全文大小：420K
- ISSN：1528-7505
文摘
A solvent-assisted solid-to-solid polymorphic transition, which was assumed to be one of the key processes for the occurrence of preferential enrichment (PE), has been proven to occur by means of temperature-controlled video-microscopy (TCVM) and time-resolved in situ X-ray powder diffraction (XRPD) measurement during crystallization of two typical first-generation chiral racemic compounds (1 and 2) showing an excellent PE phenomenon.