One-Pot Synthesis of Hybrid Macrocyclic Pentamers with Variable Functionalizations around the Periphery

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• 作者：Bo Qin ; Chang Sun ; Ying Liu ; Jie Shen ; Ruijuan Ye ; Jia Zhu ; Xin-Fang Duan ; Huaqiang Zeng
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：May 6, 2011
• 年：2011
• 卷：13
• 期：9
• 页码：2270-2273
• 全文大小：734K
• 年卷期：v.13,no.9(May 6, 2011)
• ISSN：1523-7052

文摘

Rather than four- or six-residue macrocylces, one-pot macrocyclization allows for the highly selective formation of five-residue macrocycles rigidified by intramolecular hydrogen bonds. Variable functionalizations around the pentameric periphery were achieved by reacting monomers with higher oligomers bearing different exterior side chains. The formation of these hybrid pentamers suggests a chain-growth mechanism for the one-pot macrocyclization where the successive addition of monomers onto higher oligomers is faster than those between two monomers or two higher oligomers.