In Situ Growth of Self-Assembled Protein–Polymer Nanovesicles for Enhanced Intracellular Protein Delivery

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• 作者：Xinyu Liu ; Weiping Gao
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2017
• 出版时间：January 25, 2017
• 年：2017
• 卷：9
• 期：3
• 页码：2023-2028
• 全文大小：411K
• ISSN：1944-8252

文摘

We report a new and general method, in situ growth, for designing self-assembled protein–polymer nanovesicles for intracellular protein delivery.In situ polymerization of a water-soluble monomer from a protein attached with a polymerization initiator yields amphiphilic protein conjugates of a water-insoluble polymer. These conjugates can in situ self-assemble into nanostructures with tunable morphologies from spheres to vesicles. Interestingly, an exogenous protein can be in situ encapsulated inside protein–polymer nanovesicles for enhanced intracellular protein delivery. The in situ growth method may open up new opportunities for designing a variety of self-assembled protein–polymer nanostructures tailored to specific applications.