Phytochemicals from Cunninghamia konishii Hayata Act as Antifungal Agents
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- 作者：Sen-Sung Cheng ; Min-Jay Chung ; Chun-Ya Lin ; Ya-Nan Wang ; Shang-Tzen Chang
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2012
- 出版时间：January 11, 2012
- 年：2012
- 卷：60
- 期：1
- 页码：124-128
- 全文大小：262K
- 年卷期：v.60,no.1(January 11, 2012)
- ISSN：1520-5118
文摘
The aims of the present study were to isolate and identify the antifungal compounds from the ethanolic extract of Cunninghamia konishii wood and to evaluate their antifungal activities against wood decay fungi. The results showed that the n-Hex soluble fraction of the ethanolic extract from C. konishii wood had an excellent inhibitory effect against Lenzites betulina, Trametes versicolor, Laetiporus sulphureus, and Gloeophyllum trabeum, with IC50 values of 33, 46, 62, and 49 渭g/mL, respectively. By following the bioactivity-guided fractionation procedure, four sesquiterpenes, T-cadinol, cedrol, T-muurolol, and (鈭?-epi-cedrol, and three diterpenes, 13-epi-manool, cis-abienol, and isoabienol, were identified from the active subfractions. Among the main constituents of the ethanolic extract from C. konishii, T-cadinol, cedrol, and T-muurolol efficiently inhibited the growth of four wood-rot fungi at the concentration of 100 渭g/mL, with antifungal indices of 51.4鈥?00.0%, 68.3鈥?00.0%, and 39.5鈥?00.0%, respectively. Results of this study show that the ethanolic extract of C. konishii wood may be considered as a potent source of T-cadinol, cedrol, and T-muurolol as new natural antifungal agents.