Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo
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- 作者：Tuo Wei ; Juan Liu ; Huili Ma ; Qiang Cheng ; Yuanyu Huang ; Jing Zhao ; Shuaidong Huo ; Xiangdong Xue ; Zicai Liang ; Xing-Jie Liang
- 刊名：Nano Letters
- 出版年：2013
- 出版时间：June 12, 2013
- 年：2013
- 卷：13
- 期：6
- 页码：2528-2534
- 全文大小：521K
- 年卷期：v.13,no.6(June 12, 2013)
- ISSN：1530-6992
文摘
Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale micelles. The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo.