Rapid Screening of Aqueous Chemical Warfare Agent Degradation Products: Ambient Pressure Ion Mobility Mass Spectrometry

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• 作者：Wes E. Steiner ; Brian H. Clowers ; Laura M. Matz ; William F. Siems ; and Herbert H. Hill ; Jr.
• 刊名：Analytical Chemistry
• 出版年：2002
• 出版时间：September 1, 2002
• 年：2002
• 卷：74
• 期：17
• 页码：4343 - 4352
• 全文大小：178K
• 年卷期：v.74,no.17(September 1, 2002)
• ISSN：1520-6882

文摘

The use of electrospray ionization ambient pressure ionmobility spectrometry with an orthogonal reflector time-of-flight mass spectrometer to analyze chemical warfare(CW) degradation products from aqueous environmentalsamples has been demonstrated. Certified referencematerials of analytical standards for the detection ofSchedule 1, 2, or 3 toxic chemicals or their precursorsas defined by the chemical warfare convention treatyverification were used in this study. A combination of sixG/V-type nerve and four S-type vesicant related CW agentdegradation products were separated with baseline resolution by this instrumental technique. Analytical figuresof merit for each CW degradation product were determined. In some cases, reduced mobility constants (K_o)have been reported for the first time. Linear responseranges for the selected CW degradation products werefound to be generally ~2 orders of magnitude, where theoverall dynamic response ranges were found to extend to4 orders of magnitude. Limits of detection for five of thenine chemical products tested were found to be less than1 ppm. To demonstrate the potential of this instrumentalmethod with complex mixtures, four CW degradationproducts were separated and detected from a spikedPalouse River water sample in less than 1 min. Finally, ahomologous series of n-alkylamines were used as baselinereference standards, producing a mobility/mass trend lineto which the CW degradation products could be compared. Comparison of these products in this manner isexpected to reduce the number of false positive/negativeresponses.