Resolved P-Metalated Nucleoside Phosphoramidites
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- 作者：Erica J. Miller ; Kevin J. Garcia ; Erin C. Holahan ; Rosa M. Ciccarelli ; Rachel A. Bergin ; Stephanie L. Casino ; Tyler L. Bogaczyk ; Michael R. Krout ; Peter M. Findeis ; Robert A. Stockland ; Jr.
- 刊名：Inorganic Chemistry
- 出版年：2014
- 出版时间：December 15, 2014
- 年：2014
- 卷：53
- 期：24
- 页码：12680-12682
- 全文大小：232K
- ISSN：1520-510X
文摘
The synthesis of resolved P-metalated nucleoside phosphoramidites is described. These rare compounds were initially prepared with gold as the metal center; however, the gold can be removed using basic phosphines or solid-supported triphenylphosphine. Treatment of the free nucleoside phosphoramidite with a platinum source generated a unique platinated dinucleoside species with a diastereomeric ratio of >99:1.