Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma
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- 作者：Stuart T. Onions ; Kazuhiro Ito ; Catherine E. Charron ; Richard J. Brown ; Marie Colucci ; Fritz Frickel ; George Hardy ; Kevin Joly ; John King-Underwood ; Yasuo Kizawa ; Ian Knowles ; P. John Murray ; Andrew Novak ; Anjna Rani ; Garth Rapeport ; Alun Smith ; Peter Strong ; David M. Taddei ; Jonathan G. Williams
- 刊名：Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：March 10, 2016
- 年：2016
- 卷：59
- 期：5
- 页码：1727-1746
- 全文大小：839K
- ISSN：1520-4804
文摘
The discovery of a novel series of therapeutic agents that has been designed and optimized for treating chronic obstructive pulmonary disease is reported. The pharmacological strategy was based on the identification of compounds that inhibit a defined subset of kinase enzymes modulating inflammatory processes that would be effective against steroid refractory disease and exhibit a sustained duration of action after inhaled delivery.