Antiproliferative Withanolides from Datura wrightii

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• 作者：Huaping Zhang ; Joseph Bazzill ; Robert J. Gallagher ; Chitra Subramanian ; Patrick T. Grogan ; Victor W. Day ; Kelly Kindscher ; Mark S. Cohen ; Barbara N. Timmermann
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：March 22, 2013
• 年：2013
• 卷：76
• 期：3
• 页码：445-449
• 全文大小：247K
• 年卷期：v.76,no.3(March 22, 2013)
• ISSN：1520-6025

文摘

A new withanolide, named withawrightolide (1), and four known withanolides (2鈥?b>5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and other spectroscopic techniques. In addition, the structure of withametelin L (2) was confirmed by X-ray crystallographic analysis. Using MTS viability assays, withanolides 1鈥?b>5 showed antiproliferative activities against human glioblastoma (U251 and U87), head and neck squamous cell carcinoma (MDA-1986), and normal fetal lung fibroblast (MRC-5) cells with IC₅₀ values in the range between 0.56 and 5.6 渭M.