New Electrophilic Difluoromethylating Reagent

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• 作者：G. K. Surya Prakash ; Csaba Weber ; Sujith Chacko ; George A. Olah
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：May 10, 2007
• 年：2007
• 卷：9
• 期：10
• 页码：1863 - 1866
• 全文大小：74K
• 年卷期：v.9,no.10(May 10, 2007)
• ISSN：1523-7052

文摘

A new electrophilic difluoromethylating reagent has been developed. The S-(difluoromethyl)diarylsulfonium tetrafluoroborate has been shownto be effective for the introduction of an electrophilic difluoromethyl group into the following nucleophiles: sulfonic acids, tertiary amines,imidazole derivatives, and phosphines. The reagent failed to transfer the difluoromethyl group to phenols, carbon nucleophiles, and primaryand secondary amines.