Actinoallolides A鈥揈, New Anti-trypanosomal Macrolides, Produced by an Endophytic Actinomycete, Actinoallomurus fulvus MK10-036
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- 作者：Yuki Inahashi ; Masato Iwatsuki ; Aki Ishiyama ; Atsuko Matsumoto ; Tomoyasu Hirose ; Jun Oshita ; Toshiaki Sunazuka ; Watanalai Panbangred ; Yoko Takahashi ; Marcel Kaiser ; Kazuhiko Otoguro ; Satoshi O虆mura
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：February 20, 2015
- 年：2015
- 卷：17
- 期：4
- 页码：864-867
- 全文大小：250K
- ISSN：1523-7052
文摘
Five new anti-trypanosomal macrolides, actinoallolides A鈥揈 (1鈥?b>5), were discovered from the cultured broth of Actinoallomurus fulvus MK10-036. The structures of the actinoallolides, including absolute stereochemistry, were elucidated by a combination of spectroscopic analyses and a series of chemical derivatization studies. Actinoallolide A showed the most potent and selective in vitro anti-trypanosomal activity without cytotoxicity. A new class of promising lead compounds was identified for the development of drugs for both sleeping sickness and Chagas disease.