Iodocyclization of Ethoxyethyl Ethers to Alkynes: A Broadly Applicable Synthesis of 3-Iodobenzo[b]furans

详细信息    查看全文

• 作者：Takashi Okitsu ; Daisuke Nakazawa ; Rie Taniguchi ; Akimori Wada
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：November 6, 2008
• 年：2008
• 卷：10
• 期：21
• 页码：4967-4970
• 全文大小：164K
• 年卷期：v.10,no.21(November 6, 2008)
• ISSN：1523-7052

文摘

A wide variety of 3-iodobenzo[b]furans were readily prepared by iodocyclization of 2-alkynyl-1-(1-ethoxyethoxy)benzenes with the I(coll)₂PF₆−BF₃·OEt₂ combination. Aryl-, vinylic-, and alkyl-substituted alkynes undergo iodocyclization in good to excellent yields. The mechanism of the reaction is also discussed.