Relay Catalysis by a Metal-Complex/Brønsted Acid Binary System in a Tandem Isomerization/Carbon−Carbon Bond Forming Sequence

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• 作者：Keiichi Sorimachi ; Masahiro Terada
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：November 5, 2008
• 年：2008
• 卷：130
• 期：44
• 页码：14452-14453
• 全文大小：146K
• 年卷期：v.130,no.44(November 5, 2008)
• ISSN：1520-5126

文摘

A one-pot tandem isomerization/carbon−carbon bond forming sequence catalyzed by a ruthenium complex/Brønsted acid binary system is demonstrated. The method enables the use of readily available allylamides to deliver reactive imines under relay catalysis using a binary catalytic system. Subsequent Brønsted acid catalyzed carbon−carbon bond forming reactions of the generated imines with nucleophilic components afforded Friedel−Crafts and Mannich products in good yields.