Fungal Biotransformation Products of Dehydroabietic Acid
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- 作者：Teris A. van Beek ; Frank W. Claassen ; Jose Dorado ; Markus Godejohann ; Reyes Sierra-Alvarez ; Joannes B. P. A. Wijnberg
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：February 2007
- 年：2007
- 卷：70
- 期：2
- 页码：154 - 159
- 全文大小：61K
- 年卷期：v.70,no.2(February 2007)
- ISSN：1520-6025
文摘
Dehydroabietic acid (DHA) (1) is one of the main compounds in Scots pine wood responsible for aquatic and microbialtoxicity. The degradation of 1 by Trametes versicolor and Phlebiopsis gigantea in liquid stationary cultures was followedby HPLC-DAD-ELSD. Both fungi rapidly degraded DHA relative to a control. More breakdown products were observedfor T. versicolor than for P. gigantea. After 13 days, four compounds were identified by means of spectroscopic methodsin P. gigantea cultures: 1
-hydroxy-DHA (2), 1,7
-dihydroxy-DHA (3), 1,16-dihydroxy-DHA (5), and tentatively1-hydroxy-7-oxo-DHA (4). In T. versicolor cultures, 1,16-dihydroxy-DHA (5), 7,16-dihydroxy-DHA (6), 1,7,16-trihydroxy-DHA (7), 1,16-dihydroxy-7-oxo-DHA (8), 1,15-dihydroxy-DHA (9), and 1,7,16-trihydroxy-DHA (10)were identified after 9 days of incubation. Thus the biotransformation of 1 by the two fungi was different, with only 5being produced by both strains. Compounds 3, 7, 8, and 10 are reported for the first time as natural products.
-hydroxy-DHA (2), 1,7-dihydroxy-DHA (3), 1,16-dihydroxy-DHA (5), and tentatively1-hydroxy-7-oxo-DHA (4). In T. versicolor cultures, 1,16-dihydroxy-DHA (5), 7,16-dihydroxy-DHA (6), 1,7,16-trihydroxy-DHA (7), 1,16-dihydroxy-7-oxo-DHA (8), 1,15-dihydroxy-DHA (9), and 1,7,16-trihydroxy-DHA (10)were identified after 9 days of incubation. Thus the biotransformation of 1 by the two fungi was different, with only 5being produced by both strains. Compounds 3, 7, 8, and 10 are reported for the first time as natural products.