Au鈥揂g@Au Hollow Nanostructure with Enhanced Chemical Stability and Improved Photothermal Transduction Efficiency for Cancer Treatment

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• 作者：Tongtong Jiang ; Jiangluqi Song ; Wenting Zhang ; Hao Wang ; Xiaodong Li ; Ruixiang Xia ; Lixin Zhu ; Xiaoliang Xu
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：October 7, 2015
• 年：2015
• 卷：7
• 期：39
• 页码：21985-21994
• 全文大小：692K
• ISSN：1944-8252

文摘

Despite the fact that Au鈥揂g hollow nanoparticles (HNPs) have gained much attention as ablation agents for photothermal therapy, the instability of the Ag element limits their applications. Herein, excess Au atoms were deposited on the surface of a Au鈥揂g HNP by improving the reduction power of l-ascorbic acid (AA) and thereby preventing the reaction between HAuCl₄ and the Ag element in the Au鈥揂g alloy nanostructure. Significantly, the obtained Au鈥揂g@Au HNPs show excellent chemical stability in an oxidative environment, together with remarkable increase in extinction peak intensity and obvious narrowing in peak width. Moreover, finite-difference time-domain (FDTD) was used to simulate the optical properties and electric field distribution of HNPs. The calculated results show that the proportion of absorption cross section in total extinction cross section increases with the improvement of Au content in HNP. As predicted by the theoretical calculation results, Au鈥揂g@Au nanocages (NCs) exhibit a photothermal transduction efficiency (畏) as high as 36.5% at 808 nm, which is higher than that of Au鈥揂g NCs (31.2%). Irradiated by 808 nm laser at power densities of 1 W/cm², MCF-7 breast cancer cells incubated with PEGylated Au鈥揂g@Au NCs were seriously destroyed. Combined together, Au鈥揂g@Au HNPs with enhanced chemical stability and improved photothermal transduction efficiency show superior competitiveness as photothermal agents.