Flaxseed Oil Attenuates Nonalcoholic Fatty Liver of Hyperlipidemic Hamsters

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• 作者：Shun-Fa Yang ; Jung-Kai Tseng ; Yuan-Yen Chang ; Yi-Chen Chen
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2009
• 出版时间：June 10, 2009
• 年：2009
• 卷：57
• 期：11
• 页码：5078-5083
• 全文大小：730K
• 年卷期：v.57,no.11(June 10, 2009)
• ISSN：1520-5118

文摘

Hyperlipidemia of hamsters was induced by high-fat/cholesterol diets formulated by the addition of coconut oil (CO), butter (BU), and flaxseed oil (FX). Lower (p < 0.05) serum lipids, liver size, and hepatic cholesterol and triacylglycerol contents were observed in the FX group compared to both CO and BU groups. The liver damage indices [glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) values] in the FX group were lower (p < 0.05) than those in the CO and BU groups, which may result from higher (p < 0.05) glutathione (GSH) levels and a tendency toward lower malondialdehyde (MDA) levels in livers. Besides, lower (p < 0.05) gene expression and activity of hepatic matrix metalloproteinases-9 (MMP-9) in the FX group were lower (p > 0.05) compared to those in the CO and BU groups; however, no (p > 0.05) differences in gene expression activities of hepatic MMP-2 were observed among treatments. Those beneficial effects could explain the attenuation of FX on nonalcoholic fatty liver (NAFL) induced by a high-fat/cholesterol dietary habit.