Asymmetric Route to Pyridines Bearing a Highly Functionalized 2-Alkyl Substituent by Aziridine Ring-Opening Reactions

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• 作者：Diego Savoia ; Giuseppe Alvaro ; Romano Di Fabio ; Andrea Gualandi
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：May 11, 2007
• 年：2007
• 卷：72
• 期：10
• 页码：3859 - 3862
• 全文大小：65K
• 年卷期：v.72,no.10(May 11, 2007)
• ISSN：1520-6904

文摘

The aziridine prepared from the 2-pyridineimine derived from (S)-valinol underwent ring-opening byattack of nitrogen, sulfur, and oxygen nucleophiles. Complete or prevalent regioselectivity was obtainedusing cerium trichloride heptahydrate as a catalyst. In some cases, the N-substituent could be removedby an oxidative protocol.