Inorganic鈥揙rganic Nanocomposite Assembly Using Collagen as a Template and Sodium Tripolyphosphate as a Biomimetic Analog of Matrix Phosphoprotein

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• 作者：Lin Dai ; Yi-Pin Qi ; Li-Na Niu ; Yan Liu ; Cesar R. Pucci ; Stephen W. Looney ; Jun-Qi Ling ; David H. Pashley ; Franklin R. Tay
• 刊名：Crystal Growth & Design
• 出版年：2011
• 出版时间：August 3, 2011
• 年：2011
• 卷：11
• 期：8
• 页码：3504-3511
• 全文大小：1367K
• 年卷期：v.11,no.8(August 3, 2011)
• ISSN：1528-7505

文摘

Nanocomposites created with polycarboxylic acid alone as a stabilization agent for prenucleation clusters-derived amorphous calcium phosphate exhibit nonperiodic apatite deposition. In the present study, we report the use of inorganic polyphosphate as a biomimetic analog of matrix phosphoprotein for directing poly(acrylic acid)-stabilized amorphous nanoprecursor phases to assemble into periodic apatite-collagen nanocomposites. The sorption and desorption characteristics of sodium tripolyphosphate to type I collagen were examined. Periodic nanocomposite assembly with collagen as a template was demonstrated with TEM and SEM using a Portland cement-based resin composite and a phosphate-containing simulated body fluid. Apatite was detected within the collagen at 24 h and became more distinct at 48 h, with prenucleation clusters attaching to the collagen fibril surface during the initial infiltration stage. Apatite-collagen nanocomposites at 72 h were heavily mineralized with periodically arranged intrafibrillar apatite platelets. Defect-containing nanocomposites caused by desorption of TPP from collagen fibrils were observed in regions lacking the inorganic phase.