Photofunctional Transition Metal Complexes. Structure and Bonding, 123 Edited by Vivian W. W. Yam (The University of Hong Kong). Series edited by D. Michael P. Mingos. Springer: Berlin, Heidelberg, Ne

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• 作者：William B. Connick
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：March 26, 2008
• 年：2008
• 卷：130
• 期：12
• 页码：4205 - 4205
• 全文大小：18K
• 年卷期：v.130,no.12(March 26, 2008)
• ISSN：1520-5126

文摘

The intramolecular reaction of oxime ethers and cyclopropane diesters results in the diastereoselective formation of substituted pyrrolo-isoxazolidines which serve as precursors to the ubiquitouspyrrolidine motif. A simple reversal of addition order of catalyst and substrate results in formation of twodiscrete diastereomers in a highly selective and predictable manner. The adducts are prepared in excellentyields from either enantiomer of an alkoxyamino-tethered cyclopropanediester, allowing efficient access tohighly substituted homochiral pyrrolidines.