A Multiscale TiO2 Nanorod Array for Ultrasensitive Capture of Circulating Tumor Cells

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• 作者：Na Sun ; Xinpan Li ; Zhili Wang ; Ruihua Zhang ; Jine Wang ; Kewei Wang ; Renjun Pei
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：May 25, 2016
• 年：2016
• 卷：8
• 期：20
• 页码：12638-12643
• 全文大小：351K
• 年卷期：0
• ISSN：1944-8252

文摘

In this work, a uniform multiscale TiO₂ nanorod array is fabricated to provide a “multi-scale interacting platform” for cell capture, which exhibits excellent capture specificity and sensitivity of the target cells after modification with bovine serum albumin (BSA) and DNA aptamer. After studying the capture performance of the BSA-aptamer TiO₂ nanorod substrates and other nanostructured substrates, we can conclude that the multisacle TiO₂ nanorod substrates could indeed effectively enhance the capture yields of target cancer cells. The capture yield of artificial blood samples on the BSA-aptamer TiO₂ nanorod substrates is up to 85%–95%, revealing the potential application of the TiO₂ nanorods on efficient and sensitive capture of rare circulating tumor cells.