A Ratiometric Fluorescent Probe for Thiols Based on a Tetrakis(4-hydroxyphenyl)porphyrin鈥揅oumarin Scaffold

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• 作者：Xiaowei Cao ; Weiying Lin ; Quanxing Yu
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：September 16, 2011
• 年：2011
• 卷：76
• 期：18
• 页码：7423-7430
• 全文大小：950K
• 年卷期：v.76,no.18(September 16, 2011)
• ISSN：1520-6904

文摘

In this work, we have designed and synthesized the compound Ratio-HPSSC, based on a tetrakis(4-hydroxyphenyl)porphyrin鈥揷oumarin scaffold, as a new ratiometric fluorescent probe for thiols. The ratiometric probe Ratio-HPSSC is highly selective and sensitive to thiols. Importantly, the novel ratiometric probe exhibited a remarkable change in emission color from red to blue. This key feature allows Ratio-HPSSC to be employed for thiol detection by simple visual inspection. Furthermore, we have demonstrated that Ratio-HPSSC is suitable for ratiometric fluorescence imaging of thiols in living cells. We believe that the new ratiometric probe will find interesting applications in chemistry, biology, and medicine.