Asymmetric Methallylation of Ketones Catalyzed by a Highly Active Organocatalyst 3,3鈥?F2-BINOL

详细信息    查看全文

• 作者：Yongda Zhang ; Ning Li ; Bo Qu ; Shengli Ma ; Heewon Lee ; Nina C. Gonnella ; Joe Gao ; Wenjie Li ; Zhulin Tan ; Jonathan T. Reeves ; Jun Wang ; Jon C. Lorenz ; Guisheng Li ; Diana C. Reeves ; Ajith Premasiri ; Nelu Grinberg ; Nizar Haddad ; Bruce Z. Lu ; Jinhua J. Song ; Chris H. Senanayake
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：April 5, 2013
• 年：2013
• 卷：15
• 期：7
• 页码：1710-1713
• 全文大小：230K
• 年卷期：v.15,no.7(April 5, 2013)
• ISSN：1523-7052

文摘

(S)-3,3鈥?F₂-BINOL has been synthesized for the first time and demonstrated as a highly active organocatalyst for asymmetric methallylation of ketones. Up to 98:2 enantioselectivity and 99% yield were obtained with 5 mol % catalyst loading. The catalyst (S)-3,3鈥?F₂-BINOL could be easily recovered and reused.