The Impact of Conformational Fluctuations on Self-Assembly: Cooperative Aggregation of Archaeal Chaperonin Proteins
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- 作者：Stephen Whitelam ; Carl Rogers ; Andrea Pasqua ; Chad Paavola ; Jonathan Trent ; Phillip L. Geissler
- 刊名：Nano Letters
- 出版年：2009
- 出版时间：January 14, 2009
- 年：2009
- 卷：9
- 期：1
- 页码：292-297
- 全文大小：263K
- 年卷期：v.9,no.1(January 14, 2009)
- ISSN：1530-6992
文摘
Protein complexes called rosettasomes self-assemble in solution to form large-scale filamentous and planar structures. The relative abundance of these aggregates varies abruptly with environmental conditions and sample composition. Our simulations of a model of patchy nanoparticles can reproduce this sharp crossover, but only if particles are allowed to switch between two internal states favoring different geometries of local binding. These results demonstrate how local conformational adaptivity can fundamentally influence the cooperativity of pattern-forming dynamics.